Talk about gone in sixty seconds. Ill-discipline cost Fulham, who had fashioned a flawless away performance to be in front and in complete command at Old Trafford with three quarters of the game gone, the chance of reaching their first FA Cup semi-final in more than two decades and prolonged Manchester United’s hopes of completing a Cup treble. Aleksandar Mitrovic had plundered his first goal since the turn of the year from a well-worked corner but the Serbian followed Willian and Marco Silva in receiving red cards after he completely lost the plot in confronting Chris Kavanagh after the referee had dismissed Fulham’s Brazilian winger for handball on the line.

Silva will have to take responsibility for starting the meltdown by being sent from the dugout even before Kavanagh had finished consulting the television screen for the game’s decisive moment. The Fulham head coach hurled a water bottle in the direction of the assistant referee in anticipation of Kavanagh’s initial awarding of a corner instead of a penalty after Willian had blocked Jadon Sancho’s goalbound shot with his hand. Silva was justifiably incensed that his side had seen two strong penalty shouts of their own ignored, but his own petulance is now becoming a problem.

His early exit here prompted the sort of meltdown more common with toddlers than professionals. Willian greeted his own dismissal with a rueful smile, having worked so hard to atone for his error in attempting a back-flicked clearance on the halfway line that allowed substitute Antony to storm away from a resolute Fulham rearguard, but Mitrovic – who had not been sent off in five years at Fulham – raged at the referee, touching the official on the shoulder as he exploded with anger and suddenly the Whites were down to nine. Losing their most potent forward for three games will probably spell the end of Fulham’s European hopes, but the striker is almost certain to get a longer ban.

The most infuriating aspect of this entirely avoidable course of events is that Fulham had produced the perfect response to two derby defeats and were dominating the only all Premier League tie of the quarter finals. They were confident in possession from the outset, with Mitrovic giving Harry Maguire the runaround, and David de Gea extended early by a looping header from Issa Diop. Silva seethed after his Serbian striker was shoved over in the area by Luke Shaw – perhaps setting the tone for what came later. Andreas Pereira roamed dangerously on his return to Old Trafford, creating space for Willian, who curler from distance drifted wide.

The returning Joao Palhinha added ballast to the Fulham midfield and United looked both unbalanced and uncertain by comparison. Their first chance owed much to the pace and vision of Marcus Rashford, who teed up Wout Weghorst, whose shot lacked any conviction. Fulham continued to take the game to their hosts with a wonderful Harrison Reed run requiring an intervention from little Lisandro Martinez. Bernd Leno and Tim Ream came to the Cotttagers’ rescue in quick successive before the break to deny Marcel Sabitzer and Scott McTominay, but that frenzied finish belied Fulham’s confidence throughout the first half.

The pattern remained the same after the interval. A deft flick from Willian after a peerless Palhinha tackle released Robinson into the United area but de Gea displayed all of his agility to push the American’s effort over the bar. The visitors kept up the pressure and a clever corner return broke the deadlock. Diop inventively helped Pereira’s set play to the back post where Mitrovic fired a finish into the net, sparking delirium amongst the travelling fans.

The home side showed little in response, with Bruno Fernandes whistling a shot wide from the edge of the box after intelligent play from Rashford, and Fulham would have doubled their lead without a sensational save from their nemesis in Hamburg thirteen years ago. United’s goalkeeper might not be as nimble as he was in those Atletico Madrid days before he still clawed away a goalbound Mitrovic header to keep his side in the tie.

Eric ten Haag took off replaced an anonymous McTominay with Anthony and the electric winger immediately added a new dimension to the United attack. He created the game’s turning point, racing along the right to reach a hopeful forward ball after Willian’s samba trick had failed to clear the danger. Antony spotted Sancho in a scoring position and the England winger stepped inside Harrison Reed before shooting towards goal, only for Willian to arrive on the goal-line in the nick of time. Or so everybody thought.

The replay revealed a clear handball – similar to the pair that Kavanagh failed to spot at West Ham last year or in allowing a scrambled equaliser for Preston last term – and Willian was off. Fulham fell apart from there, even before Fernandes had stroked home the penalty and raised the volume in a previously subdued stadium. Before the visitors could reorganise with nine men, Sabitzer had steered a shot beyond Leno after slick interplay between Shaw and Sancho to turn the tie around.

A shellshocked Fulham kept fighting to the end – although not literally – but their spirited Cup run had collapsed all around them. Fernandes fired in a third in the sixth minute of stoppage time to rub salt into the wounds but this was a missed opportunity to match any in Fulham’s 144-year history without a major honour.

MANCHESTER UNITED (4-2-3-1): de Gea; Win-Bissaka, Shaw, Martinez, Maguire; McTominay (Antony 58), Sabitzer; Sancho, Rashford (Fred 83), Fernandes; Weghorst. Subs (not used): Butland, Malacia, Dalot, Malacia, Pellistri, Elanga, Mainoo.

BOOKED: Maguire.

GOALS: Fernandes (pen 75, 96), Sabitzer (77).

FULHAM (4-2-3-1): Leno, Teto (Cedric Soares 89), A. Robinson, Diop, Ream; Palhinha, Reed (James 89); Decordova-Reid (Solomon 89), Willian, Pereira (Cairney 89); Mitrovic. Subs (not used): Rodak, Adarabioyo, Lukic, Wilson, Vinicius.

BOOKED: Pereira, A. Robinson.

SENT OFF: Willian, Mitrovic.

GOALS: Mitrovic (50).

REFEREE: Chris Kavanagh (Greater Manchester).

ATTENDANCE: 73,511.