Fulham are without striker Bobby Zamora and midfielders Danny Murphy and Clint Dempsey for the trip to Wisla Krakow.
Zamora and Dempsey have both been rested, while Murphy has a knee injury though boss Martin Jol is hopeful he will be fit to face Everton on Sunday.
“Clint’s played a lot of games recently, including internationals,” said Jol. “I want Bobby fit and focused on the Everton game.”
Philippe Senderos (thigh) is also out, leading manager Martin Jol to draft in youngsters like Kerim Frei and Alex Smith.
Midfielder Simon Davies (knee) remains on the sidelines.
Fulham sit second in Group K, level on four points with leaders Twente, after a draw with the Dutch side and victory over Odense in their opening two games.
Wisla are bottom of the group having yet to register a point.